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    • 17 APR 18
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    Novel treatment restores corneal clarity in patients with bullous keratopathy

    Researchers from Japan treated bullous keratopathy with an injection of cultured human corneal endothelial cells supplemented with a rho-associated protein kinase inhibitor.
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    • 16 APR 18
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    Cataract Surgery

    Metabolic changes of the crystalline lens fibers in your eye can lead to opacification and loss of transparency of the lens in the eye over time.

    Cataract Surgery

    This could lead to vision impairment. During cataract surgery, the cloudy natural “cataract” lens in your eye is removed and replaced with a synthetic lens to restore clear vision.

    Laser cataract surgery

    Laser cataract surgery was first performed in the USA in 2010. Due to the precision,

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    • 16 APR 18
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    Retinal Patch Performs Promisingly in Clinical Trial for Dry AMD Patients

    Audio version:

    Regenerative Patch Technologies, a company developing stem-cell-derived treatments for people with retinal diseases, has reported encouraging results for the first five patients with advanced, dry age-related macular degeneration (AMD) participating in a Phase 1/2a clinical trial for its therapy – a patch comprised of a layer of retinal pigment epithelial (RPE) cells on a synthetic scaffold. The treatment is known as the California Project to Cure Blindness–Retinal Pigment Epithelium 1 (CPCB-RPE1).

    One patient in the trial had visual acuity improvement of 17 letters (about 3 lines on an eye chart) in her treated eye. Three patients had vision maintained in their treated eyes. Two had improved fixation. One patient did not receive the patch due to debris underneath the retina. No evidence of safety issues with the treatment was observed.

    The study investigators also reported anatomic improvements in the treated eyes. Imaging showed that the transplanted RPE cells integrated with photoreceptors, the cells that make vision possible.

    In people with advanced AMD, RPE cells degenerate leading to loss of photoreceptors. RPE cells provide critical support functions – including nutrition and waste management – for photoreceptors. The RPE cells used in Regenerative Patch’s emerging therapy are derived from human embryonic stem cells.

    The treatment’s scaffold mimics Bruch’s membrane, which breaks down in people with AMD. Also known as the blood-retina barrier, Bruch’s membrane works like a sieve to transport waste debris to, and nutrients from, the retina’s vasculature.

    “People with advanced dry AMD have very limited options for saving or restoring their vision,” says Stephen Rose, PhD, chief scientific officer at the Foundation Fighting Blindness. “These early results from the California Project to Cure Blindness are good news for these patients. We look forward to learning more about the therapy as the trial moves forward.”

    Initial results of the clinical trial were published online in the journal Science Translational Medicine. Authors of the paper include Mark Humayun, MD, PhD, at the University of Southern California (USC), developer of the Argus bionic retina; Amir Kashani, MD, PhD, surgeon at USC; and Dennis Clegg, PhD, at the University of California, Santa Barbara, who has been funded by the Foundation Fighting Blindness to develop scaffolding for a therapeutic retinal patch in development at the University of Wisconsin-Madison.

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    • 13 APR 18
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    Week in review: Pay raise, Von’s Vision, gonio-<em>what?</em>

    This week, a report shows ophthalmologists’ salaries are on the rise, a former Super Bowl MVP connects underprivileged children with affordable eye care and a glaucoma-detection device called the GonioPEN aims to replace the gonioscope.
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